CaaMTech Synthesizes New Psychedelic Toad Derivatives

5-MeO-2-Me-DMT fumarate and 5-MeO-2-Me-TMT iodide, are novel salts structurally similar to the psychoactive tryptamines found in the secretions of Bufo alvarius toads


CaaMTech scientists continue to introduce new molecules to the known universe with their latest published academic work, “2,5-Dimethylbufotenine and 2,5-dimethylbufotenidine: novel derivatives of natural tryptamines found in Bufo alvarius toads.” The work highlights CaaMTech’s latest scientific contributions to an area recently brought into the mainstream by hit Vice TV documentarian, Hamilton Morris.

Hamilton Morris kicks off the third season premiere of his hit Vice TV show, “Hamilton’s Pharmacopeia,” by summarizing the history of 5-MeO-DMT, beginning with the discovery that smoking Bufo alvarius toad secretions produces a powerful psychedelic experience. This experience has earned 5-MeO-DMT the nickname “The God Molecule.” To spare the toads harm, Morris extols the importance of replacing the endangered Bufo alvarius toad’s secretions with synthetic alternatives. He concludes by describing a laboratory synthesis of 5-MeO-DMT, which is believed to be the principal psychedelic compound in toad secretions.

“Hamilton Morris illustrates the potential for synthetic, well-characterized compounds such as 5-MeO-DMT. But these ancient compounds are really just the starting point for psychedelic research,” explained Dr. Andrew Chadeayne, CaaMTech CEO.  “Much like cannabis and psychedelic mushrooms, toad secretions include multiple psychoactive compounds. CaaMTech has been the first to make synthetic derivatives, salts, crystalline forms, and combinations of many of these compounds, giving us the unique opportunity to study their pharmacology and how they could contribute to an ‘Entourage Effect.’”

CaaMTech’s research picks up where Hamilton Morris’ story ends: by investigating the chemical differences between pure 5-MeO-DMT, it’s derivatives, and natural Bufo alvarius toad secretions. Bufo alvarius toad secretions contain additional, closely related tryptamine compounds to 5-MeO-DMT, including bufotenin (5-HO-DMT) and bufotenidine (5-HO-TMT). These lesser-known compounds are psychoactive and contribute to the pharmacology of natural toad secretions, unquestionably differentiating the natural compositions from pure 5-MeO-DMT. Morris pointed out the need to research these lesser-studied components in his speech at the World Bufo Alvarius Congress in 2019:

“…the only justifiable reason for milking toads right now, is to analyze the venom, figure out exactly what it contains, figure out how it changes seasonally. And then figure out a sustainable synthetic way to recreate it so that we don’t need to bother toads.”