{"id":423,"date":"2022-03-15T10:41:55","date_gmt":"2022-03-15T17:41:55","guid":{"rendered":"https:\/\/caam.tech\/?p=423"},"modified":"2022-06-08T16:43:21","modified_gmt":"2022-06-08T23:43:21","slug":"caamtech-solves-serotonin-crystal-structure","status":"publish","type":"post","link":"https:\/\/caam.tech\/caamtech-solves-serotonin-crystal-structure\/","title":{"rendered":"CaaMTech Solves Serotonin Crystal Structure"},"content":{"rendered":"\n<p>CaaMTech scientists have followed up their foundational research into the <a href=\"https:\/\/caam.tech\/caamtech-solves-crystalline-forms-of-nine-serotonin-analogs\/\">crystal structures of nine serotonin analogues<\/a> by solving the crystal structure of freebase serotonin for the first time.&nbsp; The crystallography was performed through CaaMTech\u2019s collaboration with the Manke Lab at UMass Dartmouth and published in <em>Acta Crystallographica Section E <\/em>under the title, \u201c<a href=\"https:\/\/doi.org\/10.1107\/S2056989022002559\">Crystal structure of serotonin<\/a>.\u201d&nbsp; The research fills an important gap in the scientific understanding of one of the human body\u2019s most important neurotransmitters: serotonin (5-hydroxytryptamine or 5-HT).<\/p>\n\n\n\n<p>\u201cIn studying a series of serotonin analogs, we noticed a fundamental unmet need,\u201d said <a href=\"https:\/\/caam.tech\/team\/andrew-chadeayne\/\">Dr. Andrew Chadeayne<\/a>, CEO of CaaMTech, \u201cNo one has experimentally determined the solid state structure of serotonin itself.\u201d\u201d<\/p>\n\n\n\n<p>Serotonin is one of the most important neurotransmitters in humans.&nbsp; As a result, it is one of biology\u2019s most studied chemical compounds &nbsp; Despite its importance, the crystal structure of freebase serotonin (as it exists in the human bloodstream and brain) has gone unsolved until now.<\/p>\n\n\n\n<p>\u201cGiven the importance of serotonin, the limited set of crystallographic data for compounds like these is surprising,\u201d said Dr. David R. Manke, Professor at UMass Dartmouth regarding his <a href=\"https:\/\/doi.org\/10.1107\/s2053229621008950\">previous research on serotonin analogues<\/a>.&nbsp; \u201cWe have come across several situations where solving the crystal structure reveals unexpected discrepancies in a compound\u2019s molecular weight, which could introduce errors in biological studies.\u201d<\/p>\n\n\n\n<p>Dr. Manke\u2019s comments once again highlight the significance of crystallography to downstream scientific research for serotonin and other compounds alike: without knowing the fundamental chemical properties of a compound with the certainty of X-ray crystallography (the gold standard of crystallographic characterization), significant errors can propagate through scientific research.&nbsp;<\/p>\n\n\n\n<p>\u201cWhen measuring the biological properties of a molecule, it\u2019s essential to know what the molecule is,\u201d explained Dr. Chadeayne, \u201cand with tryptamine compounds, it\u2019s easy to get fooled by different crystalline forms, so it\u2019s best to rely on physical data\u2013especially for a reference standard and baseline comparator like serotonin.\u201d<\/p>\n\n\n\n<p>CaaMTech remains committed to laying the scientific groundwork for psychedelic research through crystallography, chemistry, and fundamental science.<\/p>\n","protected":false},"excerpt":{"rendered":"<p class=\"excerpt\">CaaMTech scientists have solved the crystal structure of freebase serotonin for the first time<\/p>\n","protected":false},"author":5,"featured_media":424,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[5],"tags":[],"acf":[],"_links":{"self":[{"href":"https:\/\/caam.tech\/wp-json\/wp\/v2\/posts\/423"}],"collection":[{"href":"https:\/\/caam.tech\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/caam.tech\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/caam.tech\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/caam.tech\/wp-json\/wp\/v2\/comments?post=423"}],"version-history":[{"count":2,"href":"https:\/\/caam.tech\/wp-json\/wp\/v2\/posts\/423\/revisions"}],"predecessor-version":[{"id":449,"href":"https:\/\/caam.tech\/wp-json\/wp\/v2\/posts\/423\/revisions\/449"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/caam.tech\/wp-json\/wp\/v2\/media\/424"}],"wp:attachment":[{"href":"https:\/\/caam.tech\/wp-json\/wp\/v2\/media?parent=423"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/caam.tech\/wp-json\/wp\/v2\/categories?post=423"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/caam.tech\/wp-json\/wp\/v2\/tags?post=423"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}