{"id":326,"date":"2021-03-22T11:55:05","date_gmt":"2021-03-22T18:55:05","guid":{"rendered":"https:\/\/caam.tech\/?p=326"},"modified":"2021-03-22T11:55:09","modified_gmt":"2021-03-22T18:55:09","slug":"caamtech-synthesizes-water-soluble-foxtrot-salt","status":"publish","type":"post","link":"https:\/\/caam.tech\/caamtech-synthesizes-water-soluble-foxtrot-salt\/","title":{"rendered":"CaaMTech Synthesizes Water-Soluble ‘Foxtrot’ Salt"},"content":{"rendered":"\n
The world\u2019s preeminent tryptamine crystallographers have synthesized and crystallographically characterized yet another novel compound: 5-MeO-DALT fumarate is a water-soluble fumarate salt of 5-MeO-DALT (colloquially known as \u201cFoxtrot\u201d).\u00a0 The fumarate salt research builds on CaaMTech\u2019s previous work crystallizing and structurally characterizing 5-MeO-DALT freebase by enhancing stability, crystallinity, and the compound\u2019s water solubility.\u00a0 CaaMTech researchers reported the work in the journal Acta Cryst. E<\/em> in a paper titled, \u201c\u2018Foxtrot\u2019 fumarate: a water-soluble salt of N,N-diallyl-5-methoxytryptamine.<\/a>\u201d<\/p>\n\n\n\n 5-MeO-DALT is an orally psychoactive synthetic analogue of 5-MeO-DMT.\u00a0 The synthesis and oral activity of 5-MeO-DALT was first reported by Alexander Shulgin in 2004 and thereafter, quickly appeared for sale from online research chemical retailers. Despite its use in the years following (including in a small-scale self-administered cluster headache trial), little fundamental scientific research was conducted on 5-MeO-DALT until CaaMTech completed the first known crystallization of 5-MeO-DALT freebase in 2020<\/a>.<\/p>\n\n\n\n In addition to synthesizing novel crystalline forms of 5-MeO-DALT, CaaMTech researchers have determined their purity using nuclear magnetic resonance (NMR) and their crystal structures with X-ray crystallography: the gold standard for crystallographic characterization. This rigorous scientific treatment is essential to produce analytically pure, well-characterized compounds. Pure, well-characterized compounds are the necessary building blocks for drugs that advance to the clinic for human trials and gain approval as safe and effective consumer products.<\/p>\n\n\n\n